Neurogenic muscle (pseudo) hypertrophy of the calf was diagnosed in a 60-year-old man, who presented with chronic, painless and unilateral calf enlargement caused by a chronic S1 radiculopathy due to a lumbar disc hernia in the L5-S1 interspace. Often times you will see someone load up the seated calf raise machine and perform calf raises bouncing each rep and using about a 2" ROM. Study design: A case report of a patient with neurogenic unilateral calf hypertrophy and review of the literature are reported. This renders a false appearance of grossly enlarged muscles, referred to as pseudohypertrophy. This refers to direct changes to the filaments within each sarcomere, due to mechanical forces on muscle tissue itself. The pseudohypertrophy is most prominent in the calf muscles initially, as they are overused while functioning to stabilize the body against gravity. In Duchene muscular dystrophy (DMD), the muscles waste away and are replaced by fat and scar tissue - a process termed as fibrosis. Congenital causes of unilateral calf enlargement include hemihypertrophy syndromes, including as Klippel-Trenaunay syndrome, Proteus syndrome, macrodystrophia lipomatosa, and dystrophic muscle conditions such as Duchenne muscular … An enlarged prostate gland can cause uncomfortable urinary symptoms, such as blocking the flow of urine out of the bladder. Mechanical tension; Metabolic stress; Muscle damage; Mechanical tension. Genetics seem to play a role, but … It can also cause … When combined, they have a very ‘anabolic’ effect on the body created by molecular signalling from the initial stimulus. Answered July 7, 2017. When it comes to muscle science, it’s been theorized that hypertrophy can occur in three distinct ways. Serious causes of calf swelling and tightness are cellulitis, direct trauma to your calf, injury to the gastrocnemius and soleus muscle, lymphedema, chronic venous insufficiency, and deep venous thrombosis (DVT). While calf swelling may not always be life-threatening, sudden death may occur if a clot dislodges and moves to your lungs. Atypical Werner syndrome (Calf muscle hypertrophy) Bulbo-spinal atrophy X-linked (Calf muscle hypertrophy) Some affected individuals experience mild to severe breathing problems related to the weakness of muscles needed for breathing. Objectives: To provide further evidence that S1 radiculopathy is predisposed to develop neurogenic muscle hypertrophy. The differential diagnosis of a swelling of the calf is extensive. Muscle enlargement and hypertrophy are rare findings in neurogenic lesions. The two in combination have been reported in cases of peripheral nerve lesions, polyneuropathy, and poliomyelitis. Hypertrophy occurs as a result of a number of variables – Mechanical Tension, Muscular Damage, and Metabolic Stress. No one is exactly sure what causes hemihyperplasia, but there is some evidence that the disorder runs in families. The mechanisms of muscle hypertrophy. One of the reasons I think the calves are hard to develop is due to improper training of them. By improper training I mean using a poor range of motion (ROM). More Causes of Calf muscle hypertrophy » Causes List for Calf muscle hypertrophy. Benign prostatic hyperplasia (BPH) — also called prostate gland enlargement — is a common condition as men get older. Overgrowth (hypertrophy) of the calf muscles occurs in some people with limb-girdle muscular dystrophy.Weakening of the heart muscle (cardiomyopathy) occurs in some forms of limb-girdle muscular dystrophy. Some possible causes of Calf muscle hypertrophy or similar disorders may include: 3. 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