Dr. Nir Barzilai is the founding director of the Institute for Aging Research, the Nathan Shock Center of Excellence in the Basic Biology of Aging and the Paul… On July 16, 2020, AFAR and One Day University co-hosted a special event with AFAR Scientific Director Nir Barzilai, MD, on how to die young at a very old age. It’s public knowledge. Appearances. Q: So take us into the aging trial, TAME, that you’re conducting with metformin. Nir Barzilai M.D. Dr. Nir Barzilai: I want to do it as fast as possible. Delivering Thursday’s keynote speech at Harvard’s Nutrition and Obesity Symposium on Longevity and Aging, Barzilai challenged the common wisdom that the secret to a long life is a healthy lifestyle.The real secret, he said, lies in the genes, and the key is research. He hypothesizes that centenarians have protective genes which delay aging or protect against age-related diseases. Follow Seeking Delphi™ on Facebook @SeekingDelphi. So they’re really our enemy. A: Okay, so, basically put, our hypothesis is that aging drives disease. 28 Similar Profiles; Longevity Medicine & Life Sciences. We just haven’t measured it on all the diseases together. It says it’s new! That’s how it affects me. What’s more important is TAME’s design itself. Unfortunately, we wasted valuable time negotiating over things like this, when really we weren’t going to break past their conservative approach. In TAME (which stands for Targeting Aging with Metformin) we’ve clustered all of the major age-related diseases – cardiovascular disease, cancer, cognitive decline and mortality – and for every subject in our study we’re going to show that instead of contracting any one of them after, say, two years, you’re going to contract one in four. Together they form a unique fingerprint. We found out that the centenarians tend to have fewer children than the control group. Q: Your research into aging started in the 90s with the (still ongoing) Longevity Genes Project. The key to longevity may have less to do with lifestyle than with the predetermined makeup of your genes. Media / By LongevityForumTest! But we lost those longevity genes on the way. Not many people go on to live to 100 without medical intervention, but the people who do still happen to have a genetic variant that explains their longevity. New Buck Institute research is big news for Longevity, Study linking heart health to brain health could delay dementia, Nanoparticles to strip away senescent cell defences, Nano drug-delivery system developed for neurological disorders, Senolytic start-up gears up for clinical trials, Promising restorative therapy potentially 5 years away, “Adjust the immune system… de-age the brain”, Predicting Longevity using polygenic risk scores, A year in Longevity: progress perspectives, Rise of the superagers – sharp minds and youthful cognition, Committee blasts UK Government approach to aging, New Longevity supplement targets cognitive decline, Investing in the age of Longevity: Investment panel, Investing in the age of Longevity: Science panel. And there are lots of interesting endocrine changes that come along, as we grow older. High cholesterol creates a roughly three-fold increase in the risk of heart disease. I’m sure it will happen one day. What we want to do is extend healthspan and make people healthier for much longer. A lot of anti-aging is still filled with charlatans who will sell things with a promise even when there’s no hope. After years of planning and building, he is leading the first human trials in a drug that will directly target aging. How … Nir Barzilai has a plan. Exclusive video interview with Dave Asprey. It will be an enormous thing for the economy and our healthcare systems if we can harness that. From then on aging was of great interest to me, all the way through medical school and my residency. This time I’ll be right. And we really don’t want to kill anyone trying to get this stuff off the ground. View Nir Barzilai’s profile on LinkedIn, the world’s largest professional community. “Take this drug and you’ll live forever!” But if they’re lying and it doesn’t work, you’re too dead to sue them! In a nutshell, how does it regulate aging? 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